Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …

Oligodendrocytes are the sole myelin-producing cells in the central nervous system.
Oligodendrocyte number is tightly controlled across diverse brain regions to match local …

Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system
(CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play a …

Intracortical microelectrodes that can record and stimulate brain activity have become a
valuable technique for basic science research and clinical applications. However, long-term …

The cellular secretome is pivotal in mediating intercellular communication and coordinating
responses to stressors. Exosomes, initially recognized for their role in waste disposal, have …

Myelin, which is produced by oligodendrocytes, insulates axons to facilitate rapid and
efficient action potential propagation in the central nervous system. Traditionally viewed as a …

Sirtuins (SIRT) are a class of histone deacetylases that regulate important metabolic
pathways and play a role in several disease processes. Of the seven mammalian homologs …

Caloric restriction is the chronic reduction of total caloric intake without malnutrition and has
attracted a lot of attention as, among multiple other effects, it attenuates demyelination and …

ABSTRACT PARP (poly (ADP-ribose) polymerase) inhibitors have demonstrated promising
clinical activity in multiple homologous recombination (HR) deficiency tumors. However …