An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …

Alzheimer's disease (AD) is a neurodegenerative disorder accounting for over 50% of all
dementia patients and representing a leading cause of death worldwide for the global …

Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Microglia represent the first line of immune feedback in the brain. Beyond immune
surveillance, they are essential for maintaining brain homeostasis. Recent research has …

Background Masitinib is an orally administered tyrosine kinase inhibitor that targets
activated cells of the neuroimmune system (mast cells and microglia). Study AB09004 …

Microglia, brain resident immune cells, modulate development, activity, and plasticity of the
central nervous system. Mechanistically implicated in numerous neurological pathologies …

Aging can cause morphological transformation in human microglia indicative of cell
senescence, termed microglial dystrophy. However, cellular senescence is characterized by …