The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

Background Inflammation links to atherosclerosis and its complications in various
experimental investigations. Animal studies have implicated numerous inflammatory …

Long-term epigenetic reprogramming of innate immune cells in response to microbes, also
termed" trained immunity," causes prolonged altered cellular functionality to protect from …

Physicians have traditionally viewed ischemic heart disease in a cardiocentric manner:
plaques grow in arteries until they block blood flow, causing acute coronary and other …

Confinement to the home and psychological distress due to the coronavirus disease 2019
(COVID-19) pandemic may lead to harmful health behaviors, such as overeating, sedentary …

US8034337B2 - Interleukin-1α antibodies - Google Patents US8034337B2 - Interleukin-1α
antibodies - Google Patents Interleukin-1α antibodies Download PDF Info Publication number …

Recently, it has been recognized that oral infection, especially periodontitis, may affect the
course and pathogenesis of a number of systemic diseases, such as cardiovascular …

It is our central hypothesis that periodontal diseases, which are chronic Gramnegative
infections, represent a previously unrecognized risk factor for atherosclerosis and …

Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich
arterial extracellular matrix. Proteases potentially involved in these processes remain …

Thirty years ago, John French wrote a seminal review describing the unique properties of
the arterial intima. 1 His major point was that the smooth muscle cells of the intima have a …