Mechanisms of deep brain stimulation

TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Insights into the mechanisms of deep brain stimulation

K Ashkan, P Rogers, H Bergman… - Nature Reviews …, 2017 - nature.com
Despite long-term and widespread use of deep brain stimulation (DBS) in a variety of
neurological conditions, the underlying mechanisms of action have been elusive. Growing …

[HTML][HTML] Probing and regulating dysfunctional circuits using deep brain stimulation

AM Lozano, N Lipsman - Neuron, 2013 - cell.com
Despite the best available medical treatments, many patients continue to be disabled by
neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging …

Deep brain stimulation

JS Perlmutter, JW Mink - Annu. Rev. Neurosci., 2006 - annualreviews.org
Deep brain stimulation (DBS) has provided remarkable benefits for people with a variety of
neurologic conditions. Stimulation of the ventral intermediate nucleus of the thalamus can …

Translational principles of deep brain stimulation

ML Kringelbach, N Jenkinson, SLF Owen… - Nature Reviews …, 2007 - nature.com
Deep brain stimulation (DBS) has shown remarkable therapeutic benefits for patients with
otherwise treatment-resistant movement and affective disorders. This technique is not only …

An update on best practice of deep brain stimulation in Parkinson's disease

CJ Hartmann, S Fliegen, SJ Groiss… - Therapeutic …, 2019 - journals.sagepub.com
During the last 30 years, deep brain stimulation (DBS) has evolved into the clinical standard
of care as a highly effective treatment for advanced Parkinson's disease. Careful patient …

Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease

A Stefani, AM Lozano, A Peppe, P Stanzione, S Galati… - Brain, 2007 - academic.oup.com
Gait disturbances and akinesia are extremely disabling in advanced Parkinson's disease. It
has been suggested that modulation of the activity of the pedunculopontine nucleus (PPN) …

Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain

MP Kelly - Cellular signalling, 2018 - Elsevier
Deficits in brain function that are associated with aging and age-related diseases benefit
very little from currently available therapies, suggesting a better understanding of the …

Deep brain stimulation mechanisms: the control of network activity via neurochemistry modulation

CC McIntyre, RW Anderson - Journal of Neurochemistry, 2016 - Wiley Online Library
Deep brain stimulation (DBS) has revolutionized the clinical care of late‐stage Parkinson's
disease and shows promise for improving the treatment of intractable neuropsychiatric …

Mechanisms of action of deep brain stimulation (DBS)

EB Montgomery Jr, JT Gale - Neuroscience & Biobehavioral Reviews, 2008 - Elsevier
Deep brain stimulation (DBS) is remarkably effective for a range of neurological and
psychiatric disorders that have failed pharmacological and cell transplant therapies. Clinical …