Applications of ruthenium complex in tumor diagnosis and therapy

K Lin, ZZ Zhao, HB Bo, XJ Hao, JQ Wang - Frontiers in Pharmacology, 2018 - frontiersin.org
Ruthenium complexes are a new generation of metal antitumor drugs that are currently of
great interest in multidisciplinary research. In this review article, we introduce the …

An overview of the potential medicinal and pharmaceutical properties of Ru (II)/(III) complexes

A Skoczynska, A Lewinski, M Pokora, P Paneth… - International Journal of …, 2023 - mdpi.com
This review examines the existing knowledge about Ru (II)/(III) ion complexes with a
potential application in medicine or pharmacy, which may offer greater potential in cancer …

New ruthenium-xanthoxylin complex eliminates colorectal cancer stem cells by targeting the heat shock protein 90 chaperone

LS Santos, VR Silva, MVL de Castro, RB Dias… - Cell Death & …, 2023 - nature.com
In this work, we describe a novel ruthenium-xanthoxylin complex,[Ru (phen) 2
(xant)](PF6)(RXC), that can eliminate colorectal cancer (CRC) stem cells by targeting the …

Molecular design, spectroscopic, DFT, pharmacological, and molecular docking studies of novel ruthenium (III)–Schiff base complex: An inhibitor of progression in …

AFH Noureldeen, SW Aziz, SA Shouman… - International journal of …, 2022 - mdpi.com
A novel ruthenium (III)–pyrimidine Schiff base was synthesized and characterized using
different analytical and spectroscopic techniques. Molecular geometries of the ligand and …

A novel ruthenium complex with 5-fluorouracil suppresses colorectal cancer stem cells by inhibiting Akt/mTOR signaling

VR Silva, LS Santos, MVL de Castro, RB Dias… - Cell Death …, 2023 - nature.com
Abstract [Ru (5-FU)(PPh3) 2 (bipy)] PF6 (Ru/5-FU) is a novel ruthenium complex with 5-
fluorouracil with promising potential against colorectal cancer (CRC). In the present study …

Cytostatic and anti-tumor potential of Ajwa date pulp against human hepatocellular carcinoma HepG2 cells

S Siddiqui, R Ahmad, MA Khan, S Upadhyay… - Scientific reports, 2019 - nature.com
Ajwa dates (Phoenix dactylifera L.) are used by traditional therapeutic practitioners for
several health benefits but most remain to be scientifically validated. In this study, we …

Organoruthenium complexes with benzo-fused pyrithiones overcome platinum resistance in ovarian cancer cells

J Kladnik, JPC Coverdale, J Kljun, H Burmeister… - Cancers, 2021 - mdpi.com
Simple Summary Ovarian cancer is the fifth most common cancer in the developing world,
with many front-line treatments combining paclitaxel with platinum-based anticancer agents …

Novel lawsone-containing ruthenium (II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells

RA De Grandis, PWS Dos Santos, KM de Oliveira… - Bioorganic …, 2019 - Elsevier
This study describes a series of newly synthesized phosphine/diimine ruthenium complexes
containing the lawsone as bioligand with enhanced cytotoxicity against different cancer …

[HTML][HTML] A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK …

MS Oliveira, MIF Barbosa, TB de Souza, DRM Moreira… - Redox Biology, 2019 - Elsevier
Piplartine (piperlongumine) is a plant-derived compound found in some Piper species that
became a novel potential antineoplastic agent. In the present study, we synthesized a novel …

Two novel Pd thiosemicarbazone complexes as efficient and selective antitumoral drugs

T Hidalgo, D Fabra, R Allende, AI Matesanz… - Inorganic Chemistry …, 2023 - pubs.rsc.org
Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in
2020. Palladium complexes can be used as anticancer and pharmacological agents as a …