The composition of the gut microbiota is in constant flow under the influence of factors such
as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota …

Over the last years, the biopharmaceutical industry has significantly turned its biologics
production towards mammalian cell expression systems. The presence of glycosylation …

During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

Human milk oligosaccharides (HMOs) are a family of structurally diverse unconjugated
glycans that are highly abundant in and unique to human milk. Originally, HMOs were …

Understanding the impact of glycosylation and keeping a close control on glycosylation of
product candidates are required for both novel and biosimilar monoclonal antibodies (mAbs) …

Critical quality attributes (CQA) are physical, chemical, biological or microbiological
properties or characteristics that must be within an appropriate limit, range or distribution to …

Cancer immunotherapy in the form of immune checkpoint inhibitors and cellular therapies
has improved the treatment and prognosis of many patients. Nevertheless, most cancers are …

A well known, epidemiologically reproducible risk factor for human carcinomas is the long-
term consumption of “red meat” of mammalian origin. Although multiple theories have …

To treat unilateral limbal stem cell (LSC) deficiency, we developed cultivated autologous
limbal epithelial cells (CALEC) using an innovative xenobiotic-free, serum-free, antibiotic …

Protein glycosylation is post-translational modification (PTM) which is important for
pharmacokinetics and immunogenicity of recombinant glycoprotein therapeutics. As a result …