The extracellular matrix (ECM) provides structural support and imparts a wide variety of
environmental cues to cells. In the past decade, a growing body of work revealed that the …

Genomic studies of lung adenocarcinoma (LUAD) have advanced our understanding of the
disease's biology and accelerated targeted therapy. However, the proteomic characteristics …

Current management of severe asthma relying either on guidelines (bulk approach) or on
disease phenotypes (stratified approach) did not improve the burden of the disease. Several …

Small airways (< 2 mm in diameter) are probably involved across almost all asthma
severities and they show proportionally more structural and functional abnormalities with …

Endothelial integrity is vital for homeostasis and adjusted to tissue demands. Although fluid
uptake by lymphatic capillaries is a critical attribute of the lymphatic vasculature, the barrier …

Lung function declines as people age and their lungs become stiffer. With an increasing
elderly population, understanding mechanisms that contribute to these structural and …

The human airways are complex structures with important interactions between cells,
extracellular matrix (ECM) proteins and the biomechanical microenvironment. A robust, well …

Background Metastasis refers to the spread of cancer cells from a primary tumor to other
parts of the body via the lymphatic system and bloodstream. With tremendous effort over the …

Peptide-based supramolecular gels can be designed to be functional “smart” materials that
have applications in drug delivery, tissue engineering, and supramolecular chemistry …

Severe asthma induces substantial mortality and chronic disability due to intractable airway
obstruction, which may become resistant to currently available therapies including …