[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
CDK9 keeps RNA polymerase II on track
S Egloff - Cellular and Molecular Life Sciences, 2021 - Springer
Abstract Cyclin-dependent kinase 9 (CDK9), the kinase component of positive transcription
elongation factor b (P-TEFb), is essential for transcription of most protein-coding genes by …
elongation factor b (P-TEFb), is essential for transcription of most protein-coding genes by …
[HTML][HTML] RNA promotes the formation of spatial compartments in the nucleus
RNA, DNA, and protein molecules are highly organized within three-dimensional (3D)
structures in the nucleus. Although RNA has been proposed to play a role in nuclear …
structures in the nucleus. Although RNA has been proposed to play a role in nuclear …
RNAInter v4. 0: RNA interactome repository with redefined confidence scoring system and improved accessibility
J Kang, Q Tang, J He, L Li, N Yang, S Yu… - Nucleic acids …, 2022 - academic.oup.com
Establishing an RNA-associated interaction repository facilitates the system-level
understanding of RNA functions. However, as these interactions are distributed throughout …
understanding of RNA functions. However, as these interactions are distributed throughout …
Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression
Whole-genome sequencing of longitudinal tumor pairs representing transformation of
follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements …
follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements …
ecDNA hubs drive cooperative intermolecular oncogene expression
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high
expression of oncogenes through gene amplification and altered gene regulation. Gene …
expression of oncogenes through gene amplification and altered gene regulation. Gene …
Cohesin-dependence of neuronal gene expression relates to chromatin loop length
Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is
still emerging. Here, we show a prominent role for cohesin in the expression of genes that …
still emerging. Here, we show a prominent role for cohesin in the expression of genes that …
Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
Summary Polycomb repressive complex 2 (PRC2) is reported to bind to many RNAs and
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
Identification of significant chromatin contacts from HiChIP data by FitHiChIP
HiChIP/PLAC-seq is increasingly becoming popular for profiling 3D chromatin contacts
among regulatory elements and for annotating functions of genetic variants. Here we …
among regulatory elements and for annotating functions of genetic variants. Here we …
Regulatory non-coding RNAs: everything is possible, but what is important?
In recent years, the number of annotated noncoding RNAs (ncRNAs) and RNA-binding
proteins (RBPs) has increased dramatically. The wide range of RBPs identified highlights …
proteins (RBPs) has increased dramatically. The wide range of RBPs identified highlights …