Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy

A Movahedpour, O Vakili, M Khalifeh… - Cell biochemistry …, 2022 - Wiley Online Library
Traumatic brain injury (TBI) is one of the most concerning health issues in which the normal
brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of …

Traumatic brain injury and hippocampal neurogenesis: Functional implications

JB Redell, ME Maynard, EL Underwood, SM Vita… - Experimental …, 2020 - Elsevier
In the adult brain, self-renewing radial-glia like (RGL) progenitor cells have been shown to
reside in the subventricular zone and the subgranular zone of the hippocampus. A large …

Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI

Y Chen, J Meng, Q Xu, T Long, F Bi, C Chang, W Liu - Brain research, 2019 - Elsevier
Inflammation is the focus of many studies on traumatic brain injury (TBI) treatment and
outcomes improvement. Some studies have demonstrated that the inhibition of NOD-like …

Multi-dimensional mapping of brain-derived extracellular vesicle microRNA biomarker for traumatic brain injury diagnostics

J Ko, M Hemphill, Z Yang, K Beard, E Sewell… - Journal of …, 2020 - liebertpub.com
The diagnosis and prognosis of traumatic brain injury (TBI) is complicated by variability in
the type and severity of injuries and the multiple endophenotypes that describe each …

A mouse model of repetitive blast traumatic brain injury reveals post-trauma seizures and increased neuronal excitability

V Bugay, E Bozdemir, FA Vigil, SH Chun… - Journal of …, 2020 - liebertpub.com
Repetitive blast traumatic brain injury (TBI) affects numerous soldiers on the battlefield. Mild
TBI has been shown to have long-lasting effects with repeated injury. We have investigated …

Adult born dentate granule cell mediated upregulation of feedback inhibition in a mouse model of traumatic brain injury

YJ Kang, SH Lee, JA Boychuk, CR Butler… - Journal of …, 2022 - Soc Neuroscience
Post-traumatic epilepsy (PTE) and behavioral comorbidities frequently develop after
traumatic brain injury (TBI). Aberrant neurogenesis of dentate granule cells (DGCs) after TBI …

Reductions in synaptic vesicle glycoprotein 2 isoforms in the cortex and hippocampus in a rat model of traumatic brain injury

KM Fronczak, Y Li, J Henchir, CE Dixon… - Molecular …, 2021 - Springer
Traumatic brain injury (TBI) can produce lasting cognitive, emotional, and somatic difficulties
that can impact quality of life for patients living with an injury. Impaired hippocampal function …

Traumatic brain injury diminishes feedforward activation of parvalbumin-expressing interneurons in the dentate gyrus

KA Folweiler, G Xiong, KM Best, HE Metheny, G Nah… - eneuro, 2020 - eneuro.org
Traumatic brain injury (TBI) is associated with aberrant network hyperexcitability in the
dentate gyrus (DG). GABAAergic parvalbumin-expressing interneurons (PV-INs) in the DG …

Adaptive mossy cell circuit plasticity after status epilepticus

CR Butler, GL Westbrook, E Schnell - Journal of Neuroscience, 2022 - Soc Neuroscience
Hilar mossy cells regulate network function in the hippocampus through both direct
excitation and di-synaptic inhibition of dentate granule cells (DGCs). Substantial mossy cell …

Neurostimulation and reach-to-grasp function recovery following acquired brain injury: insight from pre-clinical rodent models and human applications

CFV Latchoumane, DA Barany, L Karumbaiah… - Frontiers in …, 2020 - frontiersin.org
Reach-to-grasp is an evolutionarily conserved motor function that is adversely impacted
following stroke and traumatic brain injury (TBI). Non-invasive brain stimulation (NIBS) …