Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy
Traumatic brain injury (TBI) is one of the most concerning health issues in which the normal
brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of …
brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of …
Traumatic brain injury and hippocampal neurogenesis: Functional implications
In the adult brain, self-renewing radial-glia like (RGL) progenitor cells have been shown to
reside in the subventricular zone and the subgranular zone of the hippocampus. A large …
reside in the subventricular zone and the subgranular zone of the hippocampus. A large …
Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI
Y Chen, J Meng, Q Xu, T Long, F Bi, C Chang, W Liu - Brain research, 2019 - Elsevier
Inflammation is the focus of many studies on traumatic brain injury (TBI) treatment and
outcomes improvement. Some studies have demonstrated that the inhibition of NOD-like …
outcomes improvement. Some studies have demonstrated that the inhibition of NOD-like …
Multi-dimensional mapping of brain-derived extracellular vesicle microRNA biomarker for traumatic brain injury diagnostics
The diagnosis and prognosis of traumatic brain injury (TBI) is complicated by variability in
the type and severity of injuries and the multiple endophenotypes that describe each …
the type and severity of injuries and the multiple endophenotypes that describe each …
A mouse model of repetitive blast traumatic brain injury reveals post-trauma seizures and increased neuronal excitability
V Bugay, E Bozdemir, FA Vigil, SH Chun… - Journal of …, 2020 - liebertpub.com
Repetitive blast traumatic brain injury (TBI) affects numerous soldiers on the battlefield. Mild
TBI has been shown to have long-lasting effects with repeated injury. We have investigated …
TBI has been shown to have long-lasting effects with repeated injury. We have investigated …
Adult born dentate granule cell mediated upregulation of feedback inhibition in a mouse model of traumatic brain injury
Post-traumatic epilepsy (PTE) and behavioral comorbidities frequently develop after
traumatic brain injury (TBI). Aberrant neurogenesis of dentate granule cells (DGCs) after TBI …
traumatic brain injury (TBI). Aberrant neurogenesis of dentate granule cells (DGCs) after TBI …
Reductions in synaptic vesicle glycoprotein 2 isoforms in the cortex and hippocampus in a rat model of traumatic brain injury
KM Fronczak, Y Li, J Henchir, CE Dixon… - Molecular …, 2021 - Springer
Traumatic brain injury (TBI) can produce lasting cognitive, emotional, and somatic difficulties
that can impact quality of life for patients living with an injury. Impaired hippocampal function …
that can impact quality of life for patients living with an injury. Impaired hippocampal function …
Traumatic brain injury diminishes feedforward activation of parvalbumin-expressing interneurons in the dentate gyrus
KA Folweiler, G Xiong, KM Best, HE Metheny, G Nah… - eneuro, 2020 - eneuro.org
Traumatic brain injury (TBI) is associated with aberrant network hyperexcitability in the
dentate gyrus (DG). GABAAergic parvalbumin-expressing interneurons (PV-INs) in the DG …
dentate gyrus (DG). GABAAergic parvalbumin-expressing interneurons (PV-INs) in the DG …
Adaptive mossy cell circuit plasticity after status epilepticus
Hilar mossy cells regulate network function in the hippocampus through both direct
excitation and di-synaptic inhibition of dentate granule cells (DGCs). Substantial mossy cell …
excitation and di-synaptic inhibition of dentate granule cells (DGCs). Substantial mossy cell …
Neurostimulation and reach-to-grasp function recovery following acquired brain injury: insight from pre-clinical rodent models and human applications
Reach-to-grasp is an evolutionarily conserved motor function that is adversely impacted
following stroke and traumatic brain injury (TBI). Non-invasive brain stimulation (NIBS) …
following stroke and traumatic brain injury (TBI). Non-invasive brain stimulation (NIBS) …