[HTML][HTML] Building potent chimeric antigen receptor T cells with CRISPR genome editing
Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of
hematological and solid malignancies. However, despite the success of this field, there …
hematological and solid malignancies. However, despite the success of this field, there …
Nanomedicine-combined immunotherapy for cancer
S Huang, Q Zhao - Current medicinal chemistry, 2020 - ingentaconnect.com
Background: Immunotherapy for cancer includes Chimeric Antigen Receptor (CAR)-T cells,
CAR-natural Killer (NK) cells, PD1, and the PD-L1 inhibitor. However, the proportion of …
CAR-natural Killer (NK) cells, PD1, and the PD-L1 inhibitor. However, the proportion of …
[HTML][HTML] Synergistic combination of targeted nano-nuclear-reactors and anti-PD-L1 nanobodies evokes persistent T cell immune activation for cancer immunotherapy
Background Antitumor T cell immunotherapy as a novel cancer therapeutic strategy has
shown enormous promise. However, the tumor microenvironment (TME) is characterized by …
shown enormous promise. However, the tumor microenvironment (TME) is characterized by …
[HTML][HTML] Targeting Wnt/tenascin C-mediated cross talk between pancreatic cancer cells and stellate cells via activation of the metastasis suppressor NDRG1
A major barrier to successful pancreatic cancer (PC) treatment is the surrounding stroma,
which secretes growth factors/cytokines that promote PC progression. Wnt and tenascin C …
which secretes growth factors/cytokines that promote PC progression. Wnt and tenascin C …
Nano-loaded natural killer cells as carriers of indocyanine green for synergetic cancer immunotherapy and phototherapy
To improve the efficacy of traditional chemotherapy and radiotherapy and reduce their
serious side effects, further efforts need to be exerted to identify better cancer therapeutic …
serious side effects, further efforts need to be exerted to identify better cancer therapeutic …
pH-sensitive loaded retinal/indocyanine green micelles as an “all-in-one” theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal …
In this study, pH-sensitive loaded retinal/indocyanine green (ICG) micelles were developed
to realize novel approaches for cellular senescence-photothermal synergistic therapy to …
to realize novel approaches for cellular senescence-photothermal synergistic therapy to …
Antibody Recognition of Human Epidermal Growth Factor Receptor-2 (HER2) Juxtamembrane Domain Enhances Anti-Tumor Response of Chimeric Antigen Receptor …
Chimeric antigen receptor (CAR) T cell therapy shows promise in treating malignant tumors.
However, the use of human epidermal growth factor receptor-2 (HER2) CAR-T cells carries …
However, the use of human epidermal growth factor receptor-2 (HER2) CAR-T cells carries …
[HTML][HTML] An insulin growth factor-I/II-neutralizing monoclonal antibody in combination with epidermal growth factor receptor inhibitors potently inhibits tumor cell growth
The insulin-like growth factors (IGFs), IGF-1 and IGF-II, which bind to the IGF receptor type 1
(IGF-1R) and the insulin receptor (IR), have been implicated in the growth, survival, and …
(IGF-1R) and the insulin receptor (IR), have been implicated in the growth, survival, and …
[HTML][HTML] Therapeutic antibody domains against cancer
Therapeutic antibodies represent the largest class of biotherapeutics and have proven
successful in treating various human diseases. Recent advances in antibody engineering …
successful in treating various human diseases. Recent advances in antibody engineering …
Integrated bioinformatics analysis identifies core genes in breast cancer
N Yuqin, Z Xue, W Yu, Z Shuai, S Yin, S Jiawei, L Yang… - 2019 - researchsquare.com
Background Breast cancer (BRCA) is one of the most common malignancies in women. To
reveal the molecular mechanism of the BRCA, the core genes associated with BRCA was …
reveal the molecular mechanism of the BRCA, the core genes associated with BRCA was …