Myelodysplastic syndrome and autoimmune disorders: two sides of the same coin?
MJ Hochman, AE DeZern - The Lancet Haematology, 2022 - thelancet.com
Systemic inflammatory and autoimmune diseases and myelodysplastic syndromes have
been linked in individual patients and in larger case series for at least 25 years. These …
been linked in individual patients and in larger case series for at least 25 years. These …
Somatic mutations in rheumatological diseases: VEXAS syndrome and beyond
KA Sikora, KV Wells, EC Bolek, AI Jones… - …, 2022 - academic.oup.com
Discovery of the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic)
syndrome demonstrates that somatic mutations in haematological precursor cells can cause …
syndrome demonstrates that somatic mutations in haematological precursor cells can cause …
Early activation of inflammatory pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS
Summary VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a
pleiotropic, severe autoinflammatory disease caused by somatic mutations in the ubiquitin …
pleiotropic, severe autoinflammatory disease caused by somatic mutations in the ubiquitin …
The use of immunosuppressive therapy in MDS: clinical outcomes and their predictors in a large international patient cohort
Most studies of immunosuppressive therapy (IST) in myelodysplastic syndromes (MDS) are
limited by small numbers and their single-center nature, and report conflicting data …
limited by small numbers and their single-center nature, and report conflicting data …
VEXAS syndrome in myelodysplastic syndrome with autoimmune disorder
H Huang, W Zhang, W Cai, J Liu, H Wang, T Qin… - … Hematology & Oncology, 2021 - Springer
Abstract VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a
newly-described adult-onset inflammatory syndrome characterized by vacuoles in myeloid …
newly-described adult-onset inflammatory syndrome characterized by vacuoles in myeloid …
Molecular and clinical presentation of UBA1-mutated myelodysplastic syndromes
Mutations in UBA1, which are disease-defining for VEXAS (vacuoles, E1 enzyme, X-linked,
autoinflammatory, somatic) syndrome, have been reported in patients diagnosed with …
autoinflammatory, somatic) syndrome, have been reported in patients diagnosed with …
Impact of preexisting autoimmune disease on myelodysplastic syndromes outcomes: a population analysis
D Adrianzen-Herrera, AD Sparks, R Singh… - Blood …, 2023 - ashpublications.org
Preexisting autoimmune disease affects between 10% and 30% of patients with
myelodysplastic syndromes (MDS). Studies comparing outcomes in patients with MDS with …
myelodysplastic syndromes (MDS). Studies comparing outcomes in patients with MDS with …
Somatic mutations and the risk of undifferentiated autoinflammatory disease in MDS: an under-recognized but prognostically important complication
Objectives: We theorized that myelodysplastic syndrome (MDS) with somatic mutations and
karyotype abnormalities are associated with autoinflammation, and that the presence of …
karyotype abnormalities are associated with autoinflammation, and that the presence of …
Use of immunosuppressive therapy for management of myelodysplastic syndromes: a systematic review and meta-analysis
Immunosuppressive therapy (IST) is one therapy option for treatment of patients with lower-
risk myelodysplastic syndromes (MDS). However, the use of several different …
risk myelodysplastic syndromes (MDS). However, the use of several different …
Gastrointestinal Behcet's-like disease with myelodysplastic neoplasms with trisomy 8: a French case series and literature review
N Wesner, L Drevon, A Guedon, JB Fraison… - Leukemia & …, 2019 - Taylor & Francis
We report the 11 cases of+ 8-MDS/MPN associated with Behcet's-like syndrome and
compare them with Behcet's disease and Crohn's disease, pool with literature cases for …
compare them with Behcet's disease and Crohn's disease, pool with literature cases for …