Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)
Abstract The Human BioMolecular Atlas Program (HuBMAP) aims to create a multi-scale
spatial atlas of the healthy human body at single-cell resolution by applying advanced …
spatial atlas of the healthy human body at single-cell resolution by applying advanced …
Annotation of spatially resolved single-cell data with STELLAR
Accurate cell-type annotation from spatially resolved single cells is crucial to understand
functional spatial biology that is the basis of tissue organization. However, current …
functional spatial biology that is the basis of tissue organization. However, current …
Mapping the spatial proteome of head and neck tumors: key immune mediators and metabolic determinants in the tumor microenvironment
Head and neck squamous cell carcinomas (HNSCCs) are the seventh most common cancer
and represent a global health burden. Immune checkpoint inhibitors (ICIs) have shown …
and represent a global health burden. Immune checkpoint inhibitors (ICIs) have shown …
[HTML][HTML] Specimen, biological structure, and spatial ontologies in support of a Human Reference Atlas
Abstract The Human Reference Atlas (HRA) is defined as a comprehensive, three-
dimensional (3D) atlas of all the cells in the healthy human body. It is compiled by an …
dimensional (3D) atlas of all the cells in the healthy human body. It is compiled by an …
Integration of spatial and single-cell data across modalities with weak linkage
Abstract single-cell sequencing methods have enabled the profiling of multiple types of
molecular readouts at cellular resolution, and recent developments in spatial barcoding, in …
molecular readouts at cellular resolution, and recent developments in spatial barcoding, in …
A spatial map of human macrophage niches links tissue location with function
Macrophages are the most abundant immune cell type in the tumor microenvironment
(TME). Yet the spatial distribution and cell interactions that shape macrophage function are …
(TME). Yet the spatial distribution and cell interactions that shape macrophage function are …
Transinteractome analysis reveals distinct niche requirements for isotype‐based plasma cell subsets in the bone marrow
A Bonaud, P Larraufie, M Khamyath… - European Journal of …, 2023 - Wiley Online Library
Bone marrow (BM) long‐lived plasma cells (PCs) are essential for long‐term protection
against infection, and their persistence within this organ relies on interactions with Cxcl12 …
against infection, and their persistence within this organ relies on interactions with Cxcl12 …
[HTML][HTML] A spatial map of human macrophage niches reveals context-dependent macrophage functions in colon and breast cancer
Tumor-associated macrophages (TAMs) display heterogeneous phenotypes. Yet the exact
tissue cues that shape macrophage functional diversity are incompletely understood. Here …
tissue cues that shape macrophage functional diversity are incompletely understood. Here …
[HTML][HTML] Integrating Multiplexed Imaging and Multiscale Modeling Identifies Tumor Phenotype Transformation as a Critical Component of Therapeutic T Cell Efficacy
Cancer progression is a complex process involving interactions that unfold across
molecular, cellular, and tissue scales. These multiscale interactions have been difficult to …
molecular, cellular, and tissue scales. These multiscale interactions have been difficult to …
Consensus tissue domain detection in spatial multi-omics data using MILWRM
Spatially resolved molecular assays provide high dimensional genetic, transcriptomic,
proteomic, and epigenetic information in situ and at various resolutions. Pairing these data …
proteomic, and epigenetic information in situ and at various resolutions. Pairing these data …