One of the most prominent features of the human brain is the fabulous size of the cerebral
cortex and its intricate folding. Cortical folding takes place during embryonic development …

This chapter reviews the neurological phenotype of Down syndrome (DS) in early
development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as …

Curcumin has considerable neuro-protective and anti-cancer properties but is rapidly
eliminated from the body. By optimizing the HPLC method for analysis of curcumin, this …

Autism is characterized by a broad spectrum of clinical manifestations including qualitative
impairments in social interactions and communication, and repetitive and stereotyped …

The presence of von Economo neurons (VENs) in the frontoinsular cortex (FI) has been
linked to a possible role in the integration of bodily feelings, emotional regulation, and goal …

Idiopathic epilepsies (IEs) are a group of disorders characterized by recurrent seizures in the
absence of detectable brain lesions or metabolic abnormalities. IEs include common …

Mutations conferring loss of function at the FLNA (encoding filamin A) locus lead to X-linked
periventricular nodular heterotopia (XL-PH), with seizures constituting the most common …

The rapidly emerging science of epigenetics and epigenomic medicine promises to reveal
novel insights into the susceptibility to and the onset and progression of epileptic disorders …

Tuberous sclerosis complex (TSC) is an autosomal dominant monogenetic disorder that is
characterized by the formation of benign tumors in several organs as well as brain …

Integrating the studies of epilepsy, neurosciences, computational neurosciences,
mathematics, physics, engineering, and medicine, this volume provides the first means to a …