This review summarizes our current understanding of translation in prokaryotes, focusing on
the mechanistic and structural aspects of each phase of translation: initiation, elongation …

The sequential addition of amino acids to a growing polypeptide chain is carried out by the
ribosome in a complicated multistep process called the elongation cycle. It involves accurate …

The quality of diffraction data obtained using silver and molybdenum microsources has been
compared for six model compounds with a wide range of absorption factors. The …

During peptide-bond formation on the ribosome, the α-amine of an aminoacyl-tRNA attacks
the ester carbonyl carbon of a peptidyl-tRNA to yield a peptide lengthened by one amino …

Post-transcriptional cleavage of RNA molecules to generate smaller fragments is a
widespread mechanism that enlarges the structural and functional complexity of cellular …

SUMMARY In his 2001 article,“Translation: in retrospect and prospect,” the late Carl Woese
made a prescient observation that there was a need for the then-current view of translation …

Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling
of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads …

The elongation phase of protein synthesis defines the overall speed and fidelity of protein
synthesis and affects protein folding and targeting. The mechanisms of reactions taking …

In an earlier study, β3-puromycin was used for the selection of modified ribosomes, which
were utilized for the incorporation of five different β-amino acids into Escherichia coli …

Translation of genetic information encoded in messenger RNAs into polypeptide sequences
is carried out by ribosomes in all organisms. When a full protein is synthesized, a stop codon …