Background Paediatric patients are often exposed to subtherapeutic levels or treatment
failure of β-lactams, and prolonged infusion may be beneficial. We aimed to investigate the …

The antimicrobial therapy of sepsis and septic shock should be individualized based on
pharmacokinetic/pharmacodynamic (PK/PD) parameters to deliver effective and timely …

Antibiotics are among the most utilized drugs in pediatrics. Nonetheless, there is a lack in
pharmacokinetics information for this population, and dosing criteria may vary between …

Objectives To compare the unbound plasma meropenem concentrations at mid-dosing
intervals (C mid, 50% fT), end-dosing intervals (C trough, 100% fT), and proportions of …

Piperacillin belongs to a semisynthetic group of penicillins called ureidopenicillin that have
been developed to have antipseudomonal broad spectrum activity to be used in the …

Objective Piperacillin/tazobactam (PIP/TAZ) is used for the treatment of lower respiratory
tract bacterial infections in children. This study was performed to evaluate if the current …

Optimizing antibiotic therapy is imperative with rising bacterial resistance and high infection
mortality. Extended infusion defined as a continuous infusion (COI) or prolonged infusion …

Background It is important to optimize dosing schemes of antibiotics to maximize the
probability of therapeutic success. The recommended pharmacokinetic/pharmacodynamic …

Le sepsis sévère est l'une des causes de mortalité les plus fréquentes à travers le monde.
L'étiologie la plus fréquente étant des infections causées par des bactéries, le traitement …

El uso de antibióticos en pediatría representa un reto para el personal médico, pues la
variabilidad fisiológica asociada al crecimiento y las limitaciones para obtener información …