Host obesity alters the ovarian tumor immune microenvironment and impacts response to standard of care chemotherapy

Y Liu, J Yang, TS Hilliard, Z Wang, J Johnson… - Journal of Experimental …, 2023 - Springer
Background The majority of women with epithelial ovarian cancer (OvCa) are diagnosed
with metastatic disease, resulting in a poor 5-year survival of 31%. Obesity is a recognized …

A novel six metastasis-related prognostic gene signature for patients with osteosarcoma

D Zheng, K Xia, L Yu, C Gong, Y Shi, W Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Osteosarcoma is the most common malignant bone tumor, and although there has been
significant progress in its management, metastases often herald incurable disease. Here we …

Host mesothelin expression increases ovarian cancer metastasis in the peritoneal microenvironment

TS Hilliard, B Kowalski, K Iwamoto, EA Agadi… - International journal of …, 2021 - mdpi.com
Mesothelin (MSLN), a glycoprotein normally expressed by mesothelial cells, is
overexpressed in ovarian cancer (OvCa) suggesting a role in tumor progression, although …

SPTLC2 drives an EGFR-FAK-HBEGF signaling axis to promote ovarian cancer progression

X Zhai, N Shen, T Guo, J Wang, C Xie, Y Cao, L Liu… - Oncogene, 2024 - nature.com
The epidermal growth factor receptor (EGFR) signaling pathway is frequently associated
with ovarian cancer (OC) progression. However, inhibition of EGFR signaling in OC patients …

Role of AMIGO2 in cancer progression: Novel insights

Z Tian, D Zhou, R Jiang, B Zhou - Oncology Letters, 2024 - spandidos-publications.com
Adhesion molecule with IgG-like domain 2 (AMIGO2) is a novel scaffold protein initially
identified in cerebellar granule neurons, and inhibits apoptosis of neurons. It is also widely …

The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients

K Goto, M Morimoto, M Osaki, A Tanio, R Izutsu… - BMC cancer, 2022 - Springer
Background Gastric cancer (GC) is one of the most common malignancies, and the liver is
the most common site of hematogenous metastasis of GC. AMIGO2 is a type I …

AMIGO2 characterizes cancer‐associated fibroblasts in metastatic colon cancer and induces the release of paracrine active tumorigenic secretomes

Y Yong, R Demmler, BA Zohud, Q Fang… - The Journal of …, 2024 - Wiley Online Library
Secretomes of cancer‐associated fibroblasts (CAFs) in colorectal cancer (CRC) contribute to
malignancy. Detailed knowledge is available on the components and functions of CAF …

Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal …

K Goto, M Osaki, R Izutsu, H Tanaka, R Sasaki… - Diagnostic …, 2022 - Springer
Instruction The human amphoterin-induced gene and open reading frame (AMIGO) was
identified as a novel cell adhesion molecule of type I transmembrane protein. AMIGO2 is …

AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk

Y Iida, M Osaki, S Sato, R Izutsu… - Molecular and …, 2023 - spandidos-publications.com
Patients with recurrent cervical cancer have limited treatment options and are often
considered to be incurable. Since the expression of amphoterin‑induced gene and open …

A practical spatial analysis method for elucidating the biological mechanisms of cancers with abdominal dissemination in vivo

Y Ota, S Sato, M Yoshihara, Y Nakamura, E Miyagi… - Scientific Reports, 2022 - nature.com
Elucidation of spatial interactions between cancer and host cells is important for the
development of new therapies against disseminated cancers. The aim of this study is to …