Neurodegenerative diseases of the central nervous system (CNS) are characterized by
progressive neuronal death and neurological dysfunction, leading to increased disability …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

Neurodegenerative diseases (NDDs) are incurable and debilitating conditions that result in
progressive degeneration and/or death of nerve cells in the central nervous system (CNS) …

Mutations in the gene superoxide dismutase 1 (SOD1) are causative for familial forms of the
neurodegenerative disease amyotrophic lateral sclerosis. When the first SOD1 mutations …

Amyotrophic lateral sclerosis is a complex disorder most of which is 'sporadic'of unknown
origin but approximately 10% is familial, arising from single mutations in any of more than 30 …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterised by the degeneration of upper and lower motor neurons. Recent advances in …

Amyotrophic lateral sclerosis (ALS), a common motor neuron disease affecting two per
100,000 people worldwide, encompasses at least five distinct pathological subtypes …

Cytoplasmic dynein is the main retrograde motor in all eukaryotic cells. This complex
comprises different subunits assembled on a cytoplasmic dynein heavy chain 1 (DYNC1H1) …

Oxidative stress is a common etiological feature of neurological disorders, although the
pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the
degeneration of upper and lower motor neurons. Defects in axonal transport have been …