Organelle-level precision with next-generation targeting technologies
Intracellular organelles are subsystems within a cell, whose activity and chemical
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …
Toward multi-targeted platinum and ruthenium drugs—a new paradigm in cancer drug treatment regimens?
RG Kenny, CJ Marmion - Chemical reviews, 2019 - ACS Publications
While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …
the late 1800s when Alfred Werner published his ground-breaking research on coordination …
Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
The next generation of platinum drugs: targeted Pt (II) agents, nanoparticle delivery, and Pt (IV) prodrugs
TC Johnstone, K Suntharalingam, SJ Lippard - Chemical reviews, 2016 - ACS Publications
The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …
but new platinum agents have been very slow to enter the clinic. Recently, however, there …
Noble metals in medicine: Latest advances
History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …
ancient times. For example, silver was employed in the treatment of wounds and ulcers …
An integrated view of cisplatin-induced nephrotoxicity and ototoxicity
T Karasawa, PS Steyger - Toxicology letters, 2015 - Elsevier
Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and
ototoxic side-effects remain major clinical limitations. Recent studies have improved our …
ototoxic side-effects remain major clinical limitations. Recent studies have improved our …
Functional mitochondria in health and disease
The ability to rapidly adapt cellular bioenergetic capabilities to meet rapidly changing
environmental conditions is mandatory for normal cellular function and for cancer …
environmental conditions is mandatory for normal cellular function and for cancer …
Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy
To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …
[HTML][HTML] Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives
G Battogtokh, YS Choi, DS Kang, SJ Park… - … Pharmaceutica Sinica B, 2018 - Elsevier
Mitochondrial targeting is a promising approach for solving current issues in clinical
application of chemotherapy and diagnosis of several disorders. Here, we discuss direct …
application of chemotherapy and diagnosis of several disorders. Here, we discuss direct …
New trends in platinum and palladium complexes as antineoplastic agents
The discovery of cisplatin (cis-Pt (NH 3) 2 Cl 2) as an antineoplastic agent has focussed
attention on the rational design of metal complexes that can be potentially used in cancer …
attention on the rational design of metal complexes that can be potentially used in cancer …