Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID
TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …
Immune Activation in Alzheimer Disease
Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …
efficient curative treatment available, its medical, social, and economic burdens are …
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease
Alzheimer's disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals …
dysfunctional microglial phagocytosis and complement activation. However, what signals …
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer's
disease (AD), but little is known about the molecular mechanisms underlying this regional …
disease (AD), but little is known about the molecular mechanisms underlying this regional …
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia
Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may
alter dementia onset. Mixed results are emerging from prior observational studies. To …
alter dementia onset. Mixed results are emerging from prior observational studies. To …
A Therapeutic Nanovaccine that Generates Anti‐Amyloid Antibodies and Amyloid‐specific Regulatory T Cells for Alzheimer's Disease
Abstract Alzheimer's disease (AD), the most common cause of dementia, is a complex
condition characterized by multiple pathophysiological mechanisms including amyloid‐β …
condition characterized by multiple pathophysiological mechanisms including amyloid‐β …
Oroxylin A: A promising flavonoid for prevention and treatment of chronic diseases
There have been magnificent advancements in the understanding of molecular mechanisms
of chronic diseases over the past several years, but these diseases continue to be a …
of chronic diseases over the past several years, but these diseases continue to be a …
[HTML][HTML] Gene regulation by antisense transcription: A focus on neurological and cancer diseases
Advances in high-throughput sequencing over the past decades have led to the
identification of thousands of non-coding RNAs (ncRNAs), which play a major role in …
identification of thousands of non-coding RNAs (ncRNAs), which play a major role in …
[HTML][HTML] NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in …
N Boonpraman, S Yoon, CY Kim, JS Moon, SS Yi - Redox Biology, 2023 - Elsevier
Oxidative stress and mitochondrial dysfunction have been believed to play an important role
in the pathogenesis of aging and neurodegenerative diseases, including Parkinson's …
in the pathogenesis of aging and neurodegenerative diseases, including Parkinson's …
An overview of the pharmacological activities of scopoletin against different chronic diseases
Chronic diseases are considered a major public health concern worldwide, and most of
these diseases like cancer, cardiovascular, metabolic, and neurological disorders occur due …
these diseases like cancer, cardiovascular, metabolic, and neurological disorders occur due …