Blood vessels constitute the first organ in the embryo and form the largest network in our
body but, sadly, are also often deadly. When dysregulated, the formation of new blood …

Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on
target cells and were originally discovered as mediators of directional migration of immune …

The inflammatory bowel disease ulcerative colitis (UC) frequently progresses to colon
cancer. To understand the mechanisms by which UC patients develop colon carcinomas, we …

Myeloid cells are an essential part of the glioblastoma microenvironment. However, in brain
tumors the function of these immune cells is not sufficiently clarified. In our study, we …

Obesity is associated with increased macrophage infiltration of adipose tissue, and these
macrophages may be an important component of the chronic inflammatory response playing …

An association between inflammation and cancer has long been recognized, but the cause
and effect relationship linking the two remains unclear. Myc is a pleiotropic transcription …

Chemokines are multifunctional mediators mainly responsible for leukocyte recruitment to
inflamed tissues. Cytokines of the CXC family, however, also have a pivotal role in the …

Wounds heal through a highly regulated, self-limited inflammatory response, however,
precise inflammatory mediators have not been fully delineated. In this study, we report that in …

Cancer immunotherapy relies on either restoring or activating the function of adaptive
immune cells, mainly CD8+ T lymphocytes. Despite impressive clinical success, cancer …

Intrahepatic hypoxia may occur during the inflammatory and fibrotic processes that
characterize several chronic liver diseases of viral and autoimmune origin. As a …