Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …
2-Oxoglutarate-dependent dioxygenases in cancer
JA Losman, P Koivunen, WG Kaelin Jr - Nature Reviews Cancer, 2020 - nature.com
Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …
[HTML][HTML] Mechanisms that regulate the activities of TET proteins
K Joshi, S Liu, P Breslin SJ, J Zhang - Cellular and Molecular Life Sciences, 2022 - Springer
The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
[HTML][HTML] TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
Reprogramming Müller glia to regenerate retinal neurons
M Lahne, M Nagashima, DR Hyde… - Annual Review of …, 2020 - annualreviews.org
In humans, various genetic defects or age-related diseases, such as diabetic retinopathies,
glaucoma, and macular degeneration, cause the death of retinal neurons and profound …
glaucoma, and macular degeneration, cause the death of retinal neurons and profound …
The function and regulation of TET2 in innate immunity and inflammation
B Cong, Q Zhang, X Cao - Protein & cell, 2021 - academic.oup.com
TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate-and Fe2+-
dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has …
dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has …
Roles and regulations of TET enzymes in solid tumors
The mechanisms governing the methylome profile of tumor suppressors and oncogenes
have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven …
have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven …
[HTML][HTML] Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis
The family of ten-eleven translocation dioxygenases (TETs) consists of TET1, TET2, and
TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly …
TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly …
Oxidized mitochondrial DNA released after inflammasome activation is a disease biomarker for myelodysplastic syndromes
GA Ward, KL McGraw… - Blood …, 2021 - ashpublications.org
Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic stem cell
malignancies that can phenotypically resemble other hematologic disorders. Thus, tools that …
malignancies that can phenotypically resemble other hematologic disorders. Thus, tools that …
TETology: epigenetic mastermind in action
Cytosine methylation is a well-explored epigenetic modification mediated by DNA
methyltransferases (DNMTs) which are considered “methylation writers”; cytosine …
methyltransferases (DNMTs) which are considered “methylation writers”; cytosine …