Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These
proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA …

Stress granules (SGs) contain translationally-stalled mRNAs, associated preinitiation factors,
and specific RNA-binding proteins. In addition, many signaling proteins are recruited to SGs …

Regnase-1 and Roquin are RNA binding proteins essential for degradation of inflammation-
related mRNAs and maintenance of immune homeostasis. However, their mechanistic …

Tumor necrosis factor-α (TNF-α) is the most potent proinflammatory cytokine in mammals.
The degradation of TNF-α mRNA is critical for restricting TNF-α synthesis and involves a …

Posttranscriptional control of mRNA regulates various biological processes, including
inflammatory and immune responses. RNA-binding proteins (RBPs) bind cis-regulatory …

Overactivity of the germinal center (GC) pathway resulting from accumulation of follicular
helper T (Tfh) cells causes autoimmunity, underscoring the need to understand the factors …

Processing bodies (PBs) and Stress Granules (SGs) are the founding members of a new
class of RNA granules, known as mRNA silencing foci, as they harbour transcripts …

The Roquin-1 protein binds to messenger RNAs (mRNAs) and regulates gene expression
posttranscriptionally. A single point mutation in Roquin-1, but not gene ablation, increases …

Stress granules (SGs) are mRNA-protein aggregates induced during stress, which
accumulate in many neurodegenerative diseases. Previously, the autophagy-lysosome …

Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is an RNA binding
protein. G3BP is a key component of stress granules (SGs) and can interact with many host …