Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction
S Laforest, J Labrecque, A Michaud… - Critical reviews in …, 2015 - Taylor & Francis
Obesity is a heterogeneous disease and is associated with comorbidities such as type 2
diabetes mellitus, cardiovascular disease and cancer. Several studies have examined the …
diabetes mellitus, cardiovascular disease and cancer. Several studies have examined the …
Gut microbiota Turicibacter strains differentially modify bile acids and host lipids
JB Lynch, EL Gonzalez, K Choy, KF Faull… - Nature …, 2023 - nature.com
Bacteria from the Turicibacter genus are prominent members of the mammalian gut
microbiota and correlate with alterations in dietary fat and body weight, but the specific …
microbiota and correlate with alterations in dietary fat and body weight, but the specific …
Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling
Although inflammation plays critical roles in the development of atherosclerosis, its
regulatory mechanisms remain incompletely understood. Perivascular adipose tissue …
regulatory mechanisms remain incompletely understood. Perivascular adipose tissue …
BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16
The link between branched-chain amino acids (BCAAs) and obesity has been known for
decades but the functional role of BCAA metabolism in white adipose tissue (WAT) of obese …
decades but the functional role of BCAA metabolism in white adipose tissue (WAT) of obese …
[HTML][HTML] The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy
G Wei, H Sun, K Dong, L Hu, Q Wang, Q Zhuang, Y Zhu… - Cell metabolism, 2021 - cell.com
Clear cell renal cell carcinoma (ccRCC) preferentially invades into perinephric adipose
tissue (PAT), a process associated with poor prognosis. However, the detailed mechanisms …
tissue (PAT), a process associated with poor prognosis. However, the detailed mechanisms …
TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
LA Velazquez-Villegas, A Perino, V Lemos… - Nature …, 2018 - nature.com
Remodelling of energy storing white fat into energy expending beige fat could be a
promising strategy to reduce adiposity. Here, we show that the bile acid-responsive …
promising strategy to reduce adiposity. Here, we show that the bile acid-responsive …
Exercise training in obese rats does not induce browning at thermoneutrality and induces a muscle-like signature in brown adipose tissue
Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT)
physiology in rodents housed below their thermoneutral zone (ie, 28–32° C). In these …
physiology in rodents housed below their thermoneutral zone (ie, 28–32° C). In these …
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2
Healthy adipose tissue remodeling depends on the balance between de novo adipogenesis
from adipogenic progenitor cells and the hypertrophy of adipocytes. De novo adipogenesis …
from adipogenic progenitor cells and the hypertrophy of adipocytes. De novo adipogenesis …
Adipocyte lipolysis protects mice against Trypanosoma brucei infection
Trypanosoma brucei causes African trypanosomiasis, colonizing adipose tissue and
inducing weight loss. Here we investigated the molecular mechanisms responsible for …
inducing weight loss. Here we investigated the molecular mechanisms responsible for …
[HTML][HTML] Visceral adipose tissue immune homeostasis is regulated by the crosstalk between adipocytes and dendritic cell subsets
CE Macdougall, EG Wood, J Loschko, V Scagliotti… - Cell metabolism, 2018 - cell.com
Visceral adipose tissue (VAT) has multiple roles in orchestrating whole-body energy
homeostasis. In addition, VAT is now considered an immune site harboring an array of …
homeostasis. In addition, VAT is now considered an immune site harboring an array of …