The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3
ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of …

During eukaryotic cell division, the sister chromatids of duplicated chromosomes are pulled
apart by microtubules, which connect via kinetochores. The kinetochore is a multiprotein …

Faithful chromosome segregation depends on the ability of sister kinetochores to attach to
spindle microtubules. The outer layer of kinetochores transiently expands in early mitosis to …

The tremendous diversity in eukaryotic life forms can ultimately be traced back to
evolutionary modifications at the level of molecular networks. Deep understanding of these …

Eukaryotic genes are characterized by the presence of introns that are removed from pre-
mRNA by a spliceosome. This ribonucleoprotein complex is comprised of multiple RNA …

Cells replicate and segregate their DNA with precision. Previous studies showed that these
regulated cell-cycle processes were present in the last eukaryotic common ancestor and that …

The spindle assembly checkpoint (SAC) is a cellular surveillance mechanism that functions
to ensure accurate chromosome segregation during mitosis. Macromolecular complexes …

The spindle assembly checkpoint (SAC) in animals and yeast assures equal segregation of
chromosomes during cell division. The prevalent occurrence of polyploidy in flowering …

Local phosphatase regulation is needed at kinetochores to silence the mitotic checkpoint
(aka spindle assembly checkpoint [SAC]). A key event in this regard is the …