The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …

Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly
elevated LINE1 (L1) activity. Here we report that SIRT6-deficient cells and tissues …

MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example,
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

The Sir2 family of enzymes or sirtuins are known as nicotinamide adenine dinucleotide
(NAD)-dependent deacetylases and have been implicated in the regulation of transcription …

Mammalian sirtuins have emerged in recent years as critical modulators of multiple
biological processes, regulating cellular metabolism, DNA repair, gene expression, and …

Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven
metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA …

Cellular imbalances of cholesterol and fatty acid metabolism result in pathological
processes, including atherosclerosis and metabolic syndrome. Recent work from our group …

SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …