Exploring the mystery of tumor metabolism: Warburg effect and mitochondrial metabolism fighting side by side

Y Yu, Y Jiang, C Glandorff, M Sun - Cellular Signalling, 2024 - Elsevier
The metabolic reconfiguration of tumor cells constitutes a pivotal aspect of tumor
proliferation and advancement. This study delves into two primary facets of tumor …

[HTML][HTML] N6-methyladenosine-dependent signaling in colorectal cancer: functions and clinical potential

S Liu, M Liu, Y Li, Q Song - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
Colorectal cancer (CRC) ranks as the third most prevalent malignancy worldwide. Despite
the gradual expansion of therapeutic options for CRC, its clinical management remains a …

CXCR4 regulates macrophage M1 polarization by altering glycolysis to promote prostate fibrosis

Y Zhang, C Zhang, R Feng, T Meng, W Peng… - Cell Communication and …, 2024 - Springer
Abstract Background CXC receptor 4 (CXCR4) is widely considered to be a highly
conserved G protein-coupled receptor, widely involved in the pathophysiological processes …

NXPH4 mediated by m5C contributes to the malignant characteristics of colorectal cancer via inhibiting HIF1A degradation

L Yang, J Shi, M Zhong, P Sun, X Zhang, Z Lian… - Cellular & Molecular …, 2024 - Springer
Objective Colorectal cancer (CRC) is a form of malignancy that exhibits a comparatively
elevated occurrence and fatality rate. Given the relatively slower progress in diagnostic and …

[HTML][HTML] Effects and mechanisms of N6-methyladenosine RNA methylation in environmental pollutant-induced carcinogenesis

T Li, Z Xu, K Zhang, X Yang, A Thakur, S Zeng… - Ecotoxicology and …, 2024 - Elsevier
Environmental pollution, including air pollution, plastic contamination, and heavy metal
exposure, is a pressing global issue. This crisis contributes significantly to pollution-related …

Arecoline promotes Akt‐c‐Myc‐driven aerobic glycolysis in esophageal epithelial cells

S Han, Y Chen, Y Huang, L Jin… - Environmental …, 2024 - Wiley Online Library
Aerobic glycolysis is a typical metabolic rearrangement for tumorigenesis. Arecoline is of
explicit carcinogenicity, numerous works demonstrate its mutagenicity, genotoxicity, and …

Role of prognostic gene DKK1 in oral squamous cell carcinoma

Y Liu, C Wei, S Wang, S Ding, Y Li, Y Li… - Oncology …, 2023 - spandidos-publications.com
Oral squamous cell carcinoma (OSCC) is one of the most common squamous cell
carcinomas of the head and neck. The morbidity and mortality rates of OSCC have …

Critical roles and clinical perspectives of RNA methylation in cancer

G Li, Q Yao, P Liu, H Zhang, Y Liu, S Li, Y Shi, Z Li… - MedComm, 2024 - Wiley Online Library
RNA modification, especially RNA methylation, is a critical posttranscriptional process
influencing cellular functions and disease progression, accounting for over 60% of all RNA …

Cellular and Molecular Mechanisms of the Tumor Stroma in Colorectal Cancer: Insights into Disease Progression and Therapeutic Targets

N Shakhpazyan, L Mikhaleva, A Bedzhanyan, Z Gioeva… - Biomedicines, 2023 - mdpi.com
Colorectal cancer (CRC) is a major health burden worldwide and is the third most common
type of cancer. The early detection and diagnosis of CRC is critical to improve patient …

Crucial Metabolic Networks: Cancer Progression

S Handa, M Chatterjee - Handbook of Oncobiology: From Basic to Clinical …, 2023 - Springer
The study of metabolic networks in cancer cells is essential for understanding the
fundamental properties of living systems and how metabolic dysregulation plays a role in …