Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

In contrast to many years of important research and clinical attention to the pathological
effects of alcohol (ethanol) abuse, the past several decades have seen the publication of a …

NMDA receptors promote neuronal survival but also cause cell degeneration and neuron
loss. The mechanisms underlying these opposite effects on neuronal fate are unknown …

Activation of macrophages via toll‐like receptors (TLRs) is important for inflammation and
host defense against pathogens. Recent data suggest that non‐pathogenic molecules …

Following focal cerebral ischemia (“stroke”) a complex and dynamic interaction of vascular
cells, glial cells, and neurons determines the extent of the ensuing lesion. Traditionally, the …

Sulforaphane (SUL) is one member of the isothiocyanate class of cancer chemopreventive
compounds that has been shown to be effective in blocking initiation and progression of …

Lesioning the peripheral branch of a dorsal root ganglion (DRG) neuron before injury of the
central branch of the same neuron enables spontaneous regeneration of these spinal …

We examined metallothionein (MT)‐induced neuroprotection during kainic acid (KA)‐
induced excitotoxicity by studying transgenic mice with MT‐I overexpression (TgMT mice) …

Glycogen synthase kinase-3 (GSK-3) exists as two structurally similar isoforms, α and β,
whose activities are negatively regulated by serine phosphorylation but positively controlled …

The heat shock proteins (HSPs) are members of highly conserved families of molecular
chaperones that have multiple roles in vivo. We discuss the HSPs in general, and Hsp70 …