Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Lipid metabolism disorders are the primary causes for the occurrence and progression of
various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty …

Aging women experience hormonal changes, such as decreased estrogen and increased
circulating androgen, due to natural or surgical menopause. These hormonal changes make …

Spermidine (SPD) delays age-related pathologies in various organisms. SPD
supplementation overcame the impaired immunotherapy against tumors in aged mice by …

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …

Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

Gut microbiota–diet interaction has been identified as a key factor of metabolic associated
fatty liver disease (MAFLD). Recent studies suggested that dietary polyphenols may protect …

Alterations of hepatic metabolism are critical to the development of liver disease. The
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …

Autophagy is a self-eating process of using lysosomes to degrade macromolecular
substances (eg, proteins and organelles) that are damaged, degenerated, or aging. Lipid …

Lipid metabolism is a complex biochemical process that participates in the regulation of cell
survival and death. Ferroptosis is a form of iron‐dependent regulated cell death driven by …