Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …

Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Abstract High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine
glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal …

Aberrant function of cell cycle regulators results in uncontrolled cell proliferation, making
them attractive therapeutic targets in cancer treatment. Indeed, survival of many cancers …

The tumor suppressor p53 binds prosurvival Bcl-2 family proteins such as Bcl-w and Bcl-XL
to liberate Bax, which in turn exerts proapoptotic or anti-invasive functions depending on …

Macroautophagy (hereafter called autophagy) is a vacuolar, lysosomal pathway for
catabolism of intracellular material that is conserved among eukaryotic cells. Autophagy …

Bioactive compounds are crucial for an extensive range of therapeutic uses, and some
exhibit anticancer activity. Scientists advocate that phytochemicals modulate autophagy and …

Bioactive plant derived compounds are important for a wide range of therapeutic
applications, and some display promising anticancer properties. Further evidence suggests …

Quinacrine, also known as mepacrine, has originally been used as an antimalarial drug for
close to a century, but was recently rediscovered as an anticancer agent. The mechanisms …