Sensing the oxygen and temperature in the adipose tissues–who's sensing what?

GS Kang, HJ Jo, YR Lee, T Oh, HJ Park… - Experimental & Molecular …, 2023 - nature.com
Adipose tissues, composed of various cell types, including adipocytes, endothelial cells,
neurons, and immune cells, are organs that are exposed to dynamic environmental …

Non-invasive reporter gene imaging of cell therapies, including T cells and stem cells

C Ashmore-Harris, M Iafrate, A Saleem, GO Fruhwirth - Molecular Therapy, 2020 - cell.com
Cell therapies represent a rapidly emerging class of new therapeutics. They are intended
and developed for the treatment of some of the most prevalent human diseases, including …

[HTML][HTML] Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat

J Oeckl, P Janovska, K Adamcova, K Bardova… - Molecular …, 2022 - Elsevier
Objective Classical ATP-independent non-shivering thermogenesis enabled by uncoupling
protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in …

The colorful versatility of adipocytes: white‐to‐brown transdifferentiation and its therapeutic potential in humans

S Maurer, M Harms, J Boucher - The FEBS journal, 2021 - Wiley Online Library
Brown and brite adipocytes contribute to energy expenditure through nonshivering
thermogenesis. Though these cell types are thought to arise primarily from the de novo …

Caffeic and chlorogenic acids synergistically activate browning program in human adipocytes: Implications of AMPK-and PPAR-mediated pathways

LV Vasileva, MS Savova, KM Amirova… - International Journal of …, 2020 - mdpi.com
Caffeic acid (CA) and chlorogenic acid (CGA) are phenolic compounds claimed to be
responsible for the metabolic effects of coffee and tea consumption. Along with their …

Immunometabolic links between estrogen, adipose tissue and female reproductive metabolism

SA Eaton, JK Sethi - Biology, 2019 - mdpi.com
The current knowledge of sex-dependent differences in adipose tissue biology remains in its
infancy and is motivated in part by the desire to understand why menopause is linked to an …

[HTML][HTML] Conditional gene targeting using UCP1-Cre mice directly targets the central nervous system beyond thermogenic adipose tissues

KE Claflin, KH Flippo, AI Sullivan, MC Naber… - Molecular …, 2022 - Elsevier
Abstract Objective Uncoupling protein 1 (UCP1) is a mitochondrial protein critical for
adaptive thermogenesis in adipose tissues, and it is typically believed to be restricted to …

COVID-19: Could irisin become the handyman myokine of the 21st century?

A Catalano - Coronaviruses, 2020 - ingentaconnect.com
The ongoing Coronavirus disease 2019 (COVID-19) outbreak in China has become the
world's leading health headline and is causing major panic and public concerns. After …

Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1

S Dieckmann, A Strohmeyer… - American Journal …, 2022 - journals.physiology.org
Activation of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) upon cold
stimulation leads to substantial increase in energy expenditure to defend body temperature …

[HTML][HTML] Imaging atherosclerotic plaques by targeting Galectin-3 and activated macrophages using (89Zr)-DFO-Galectin3-F (ab') 2 mAb

Z Varasteh, F De Rose, S Mohanta, Y Li, X Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: The high expression of Galectin-3 (Gal3) in macrophages of atherosclerotic
plaques suggests its participation in atherosclerosis pathogenesis, and raises the possibility …