Branched chain amino acids (BCAA) and their derivatives are bioactive molecules with
pleiotropic functions in the human body. Elevated fasting blood BCAA concentrations are …

Autophagy represents a key regulator of aging and metabolism in sensing energy
deprivation. We find that fasting in mice activates autophagy in the liver paralleled by …

Branched chain amino acids (BCAAs) are essential amino acids required by mammals.
Recently, accumulating evidence has revealed the important connection between the …

Abstract Agouti-related peptide (AgRP)-expressing and proopiomelanocortin (POMC)-
expressing neurons reciprocally regulate food intake. Here, we combine non-interacting …

Several observational studies have indicated an association between high serum levels of
branched-chain amino acids (BCAAs) and an increased risk of cardiovascular disease …

Agouti-related protein (AgRP) is a neuropeptide synthesized by AgRP/NPY neurons and
transcribed as 132 amino acids in humans and 142 amino acids (AgRP1) in Japanese …

Type 2 diabetes (T2D) is a challenging health concern worldwide. A lifestyle intervention to
treat T2D is difficult to adhere, and the effectiveness of approved medications such as …

Background High-protein diets are often enriched with branched-chain amino acids
(BCAAs) known to enhance protein synthesis and provide numerous physiological benefits …

The branched-chain amino acids (BCAAs: leucine, isoleucine and valine) are essential for
animal growth and metabolic health. However, the effect of valine on male reproduction and …

Objective The control of energy balance involves neural circuits in the central nervous
system, including AGRP neurons in the arcuate nucleus of the hypothalamus (ARC). AGRP …