High mobility group box 1 (HMGB1) is a highly conserved, nuclear protein present in all cell
types. It is a multi-facet protein exerting functions both inside and outside of cells …

SLE is characterised by an activation of the interferon (IFN) system, which leads to an
increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE …

Background The 2019 novel coronavirus disease (COVID-19) causes for unresolved
reasons acute respiratory distress syndrome in vulnerable individuals. There is a need to …

High mobility group box 1 protein (HMGB1), a highly conserved nuclear DNA-binding
protein, is a “damage-associated molecular pattern” molecule (DAMP) implicated in both …

Anti-dsDNA antibodies are pathogenically heterogeneous, implying distinct origins and
antigenic properties. Unexpectedly, during the clinical and molecular characterization of …

Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE) that
occurs in about half of patients. LN is characterized by glomerular deposition of immune …

Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely
probe the local environment and maintain host integrity. Besides pathogen recognition …

The disruption of the immune tolerance induces autoimmunity such as systemic lupus
erythematosus and vasculitis. A chromatin-binding non-histone protein, high mobility group …

The receptor for advanced glycation end products (RAGE) is a transmembrane receptor that
belongs to the immunoglobulin superfamily and is extensively associated with chronic …

Purpose and methods B cell-activating factor (BAFF) contributes to the pathogenesis of
autoimmune diseases including systemic lupus erythematosus (SLE). Although several anti …