Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

The tumor microenvironment (TME) is a major contributor to cancer malignancy including
development of therapeutic resistance, a process mediated in part through intercellular …

Aging is emerging as a druggable target with growing interest from academia, industry and
investors. New technologies such as artificial intelligence and advanced screening …

Assuring a healthy proteome is indispensable for survival and organismal health. Proteome
disbalance and the loss of the proteostasis buffer are hallmarks of various diseases. The …

Life expectancy has increased substantially over the last 150 years. Yet this means that now
most people also spend a greater length of time suffering from various age-associated …

Aging results in a decline of cellular proteostasis capacity which culminates in the
accumulation of phototoxic material, causing the onset of age-related maladies and …

The human population is aging, and the need for interventions to slow progression of age-
related diseases (geroprotective interventions) is growing. Repurposing compounds already …

Aging is the most important risk factor for the development of major life-threatening diseases
such as cardiovascular disorders, cancer, and neurodegenerative disorders. The aging …

Background Schizophrenia (SZ) is associated with increased all-cause mortality, smoking,
and age-associated proteins, yet multiple previous studies found no association between SZ …

The identification and validation of drugs that promote health during aging (“geroprotectors”)
are key to the retardation or prevention of chronic age‐related diseases. Here, we found that …