Retinal organoids: a window into human retinal development
M O'Hara-Wright, A Gonzalez-Cordero - Development, 2020 - journals.biologists.com
Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior developing brain …
networks that drive the morphogenetic transformation of the anterior developing brain …
Photoreceptor cell replacement in macular degeneration and retinitis pigmentosa: a pluripotent stem cell-based approach
G Gagliardi, KB M'Barek, O Goureau - Progress in retinal and eye research, 2019 - Elsevier
The human retina fails to regenerate and cell-based therapies offer options for treatment of
blinding retinal diseases, such as macular degeneration and retinitis pigmentosa. The last …
blinding retinal diseases, such as macular degeneration and retinitis pigmentosa. The last …
[HTML][HTML] Single-cell transcriptomic comparison of human fetal retina, hPSC-derived retinal organoids, and long-term retinal cultures
To study the development of the human retina, we use single-cell RNA sequencing (RNA-
seq) at key fetal stages and follow the development of the major cell types as well as …
seq) at key fetal stages and follow the development of the major cell types as well as …
Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development
The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …
Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin
Retinoblastoma (Rb) is the most prevalent intraocular malignancy in children, with a
worldwide survival rate< 30%. We have developed a cancerous model of Rb in retinal …
worldwide survival rate< 30%. We have developed a cancerous model of Rb in retinal …
Generating and using transcriptomically based retinal cell atlases
It has been known for over a century that the basic organization of the retina is conserved
across vertebrates. It has been equally clear that retinal cells can be classified into …
across vertebrates. It has been equally clear that retinal cells can be classified into …
Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina
B Dorgau, J Collin, A Rozanska, D Zerti… - Nature …, 2024 - nature.com
The emergence of retinal progenitor cells and differentiation to various retinal cell types
represent fundamental processes during retinal development. Herein, we provide a …
represent fundamental processes during retinal development. Herein, we provide a …
Large-scale snake genome analyses provide insights into vertebrate development
Snakes are a remarkable squamate lineage with unique morphological adaptations,
especially those related to the evolution of vertebrate skeletons, organs, and sensory …
especially those related to the evolution of vertebrate skeletons, organs, and sensory …
Human organoids for the study of retinal development and disease
CM Bell, DJ Zack, CA Berlinicke - Annual review of vision …, 2020 - annualreviews.org
Recent advances in stem cell engineering have led to an explosion in the use of organoids
as model systems for studies in multiple biological disciplines. Together with breakthroughs …
as model systems for studies in multiple biological disciplines. Together with breakthroughs …
Systematic comparison of retinal organoid differentiation from human pluripotent stem cells reveals stage specific, cell line, and methodological differences
CB Mellough, J Collin, R Queen… - Stem cells …, 2019 - academic.oup.com
A major goal in the stem cell field is to generate tissues that can be utilized as a universal
tool for in vitro models of development and disease, drug development, or as a resource for …
tool for in vitro models of development and disease, drug development, or as a resource for …