Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior developing brain …

The human retina fails to regenerate and cell-based therapies offer options for treatment of
blinding retinal diseases, such as macular degeneration and retinitis pigmentosa. The last …

To study the development of the human retina, we use single-cell RNA sequencing (RNA-
seq) at key fetal stages and follow the development of the major cell types as well as …

The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …

Retinoblastoma (Rb) is the most prevalent intraocular malignancy in children, with a
worldwide survival rate< 30%. We have developed a cancerous model of Rb in retinal …

It has been known for over a century that the basic organization of the retina is conserved
across vertebrates. It has been equally clear that retinal cells can be classified into …

The emergence of retinal progenitor cells and differentiation to various retinal cell types
represent fundamental processes during retinal development. Herein, we provide a …

Snakes are a remarkable squamate lineage with unique morphological adaptations,
especially those related to the evolution of vertebrate skeletons, organs, and sensory …

Recent advances in stem cell engineering have led to an explosion in the use of organoids
as model systems for studies in multiple biological disciplines. Together with breakthroughs …

A major goal in the stem cell field is to generate tissues that can be utilized as a universal
tool for in vitro models of development and disease, drug development, or as a resource for …