A pivotal metabolic function of insulin is the stimulation of glucose uptake into muscle and
adipose tissues. The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) …

Obesity mediates most of its direct medical sequelae through the development of insulin
resistance (IR). The cellular effects of insulin occur through two main postreceptor pathways …

Glucose transport is rate limiting for dietary glucose utilization by muscle and fat. The
glucose transporter GLUT4 is dynamically sorted and retained intracellularly and …

Background Obesity is associated with increased recurrence and reduced survival of breast
cancer. Adipocytes constitute a significant component of breast tissue, yet their role in …

Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining
whole-body glucose homeostasis. Insulin promotes glucose uptake into these tissues by …

Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in
insulin resistance. However, disentangling the individual roles of these processes in insulin …

The liver is a critical tissue for maintaining glucose, fatty acid, and cholesterol homeostasis.
Primary hepatocytes represent the gold standard for studying the mechanisms controlling …

The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback
mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin …

Insulin rapidly stimulates GLUT4 translocation and glucose transport in fat and muscle cells.
Signals from the occupied insulin receptor are translated into downstream signalling …

Adipose tissue is essential for metabolic homeostasis, balancing lipid storage and
mobilization based on nutritional status. This is coordinated by insulin, which triggers kinase …