Over the past decade, spontaneous coronary artery dissection (SCAD) has emerged as an
important cause of myocardial infarction, particularly among younger women. The pace of …

Many cardiovascular diseases are facilitated by strong inheritance. For example, large-scale
genetic studies identified hundreds of genomic loci that affect the risk of coronary artery …

Background The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial
infarction primarily affecting women. It is not known to what extent SCAD is genetically …

Abstract Aims Endothelin-1 (ET-1) is a potent vasoconstrictor peptide linked to vascular
diseases through a common intronic gene enhancer [(rs9349379-G allele), chromosome 6 …

Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of
myocardial infarction (MI), typically in young women. We undertook a genome-wide …

Introduction y objectives Spontaneous coronary artery dissection (SCAD) is a rare cause of
acute coronary syndrome. Most patients are empirically treated with beta-blockers and …

Fibromuscular dysplasia (FMD) is an arteriopathy associated with hypertension, stroke and
myocardial infarction, affecting mostly women. We report results from the first genome-wide …

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-
1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a …

Spontaneous Coronary-Artery Dissection Coronary-artery dissections account for less than
1% of acute myocardial infarctions, occur most commonly in women and most often between …