Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …

Significance: L-ergothioneine is synthesized in actinomycetes, cyanobacteria,
methylobacteria, and some fungi. In contrast to other low-molecular-weight redox buffers …

Abstract L-Ergothioneine (ET), the 2-thioimidazole derivative of trimethylhistidine, is
biosynthesized by select fungi and bacteria, notably Mycobacterium tuberculosis, and …

Gliotoxin biosynthesis is encoded by the gli gene cluster in Aspergillus fumigatus. The
biosynthesis of gliotoxin is influenced by a suite of transcriptionally-active regulatory proteins …

Using a gene disruption strategy, we generated mutants in the gliP locus of the plant-
beneficial fungus Trichoderma virens that were no longer capable of producing gliotoxin …

The threat of fungal diseases is substantially underestimated worldwide, but they have
serious consequences for humans, animals, and plants. Given the limited number of existing …

Background Filamentous fungi and bacteria form mixed-species biofilms in nature and
diverse clinical contexts. They secrete a wealth of redox-active small molecule secondary …

Epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites that share a 2, 5‐
diketopiperazine scaffold built from two amino acids and bridged by a sulfide moiety …

Fungal development and secondary metabolite production are coordinated by regulatory
complexes as the trimeric velvet complex. Light accelerates asexual but decreases sexual …

Gliotoxin is a redox-active nonribosomal peptide produced by Aspergillus fumigatus. Like
many other disulfide-containing epipolythiodioxopiperazines, a bis-thiomethylated form is …