Depression is one of the leading causes of disease worldwide. Historically conceived as
either a disease of the mind or of the brain, treatment options followed this aetiology. Current …

Objective It is a widely held belief that affective disorders are progressive of nature; however,
some recent reviews have questioned this belief. The objective of the present systematic …

This paper draws attention to an important adverse outcome in depression, the occurrence
of residual symptoms after partial remission. Among patients with definite major depression …

Background: The study tested whether level of recovery from major depressive episodes
(MDEs) predicts duration of recovery in unipolar major depressive disorder (MDD) patients …

OBJECTIVE: Although experts in the treatment of depression have suggested that achieving
remission is the primary goal of treatment, questions remain about how remission should be …

Background: This paper explores whether individuals with a mood disorder can identify the
nature and duration of depressive and manic prodromes. Methods: Seventy-three …

This paper describes the rationale and methods entailed in developing the Inventory of
Depressive Symptomatology (IDS) in both clinicianrated (IDSC) and selfreported (IDS …

OBJECTIVE: A longstanding belief among many clinicians is that patients with depression
and comorbid personality pathology have a worse response to standard depression …

During the past decade, evidence from research on mood disorders has demonstrated that
remission is the optimal outcome of treatment. However, there continues to be considerable …

Background Previous studies indicate that depressed patients with partial remission and
residual symptoms following antidepressant treatment are common and have high rates of …