Importance Hospital antimicrobial consumption data are widely available; however, large-
scale assessments of the quality of antimicrobial use in US hospitals are limited. Objective …

Intravenous beta-lactam antibiotics are the most prescribed antibiotic class in US
hospitalized patients of all ages; therefore, optimizing their dosing is crucial. Bactericidal …

Background Antibiotic-associated adverse events (AEs) in hospitalized children have not
been comprehensively characterized. Methods We conducted a retrospective observational …

The introduction of antibiotics was one of the most important medical advances of the 20th
century. However, as soon as they were introduced, antibiotics were overused. There have …

Background Antimicrobial resistance is increasingly prevalent worldwide. The inappropriate
use of antimicrobials, including in the hospital setting, is considered a major driver of …

Background Due to the high risk of severe infection among pediatric hematology and
oncology patients, antimicrobial use is particularly high. With our study, we quantitatively …

Background Antibiotics are prescribed to most pediatric intensive care unit (PICU) patients,
but data describing indications and appropriateness of antibiotic orders in this population …

BACKGROUND Nearly 25% of antibiotics prescribed to children are inappropriate or
unnecessary, subjecting patients to avoidable adverse medication effects and cost …

Introduction The most important and undesirable consequence of inappropriate antibiotic
use is the spread of antibiotic resistance, increased adverse effects, increased mortality and …

Background Most antibiotic use occurs in ambulatory settings. No benchmarks exist for
pediatric institutions to assess their outpatient antibiotic use and compare prescribing rates …