Age-related macular degeneration (AMD) is a progressive retinal disease and the major
cause of irreversible vision loss in the elderly. Numerous studies have found both common …

Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement
regulatory protein that protects host cells from injury by complement. This type-I membrane …

Thrombotic microangiopathy (TMA) is a pattern of endothelial damage that can be found in
association with diverse clinical conditions such as malignant hypertension. Although the …

Atypical hemolytic uremic syndrome (aHUS) is a life-threatening thrombotic microangiopathy
that can progress, when untreated, to end-stage renal disease. Most frequently, aHUS is …

Background Severe hypertension can induce thrombotic microangiopathy (TMA) in the renal
vasculature, the occurrence of which has been linked to mechanical stress to the …

Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening
complication of allogeneic hematopoietic cell transplantation (HCT). We hypothesized that …

Background The development of complement inhibitors has greatly improved the outcome of
patients with atypical hemolytic uremic syndrome (aHUS), making kidney transplantation a …

Importance In age-related macular degeneration (AMD), rare variants in the complement
system have been described, but their functional consequences remain largely unexplored …

Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by
microangiopathic hemolytic anemia, thrombocytopenia and renal failure. It is caused by …

Background Atypical haemolytic uremic syndrome (aHUS) is a rare but severe form of
thrombotic microangiopathy as a consequence of complement dysregulation. aHUS has a …