Research in the field of ischemia-reperfusion injury continues to be plagued by the inability
to translate research findings to clinically useful therapies. This may in part relate to the …

Innate immunity is the earliest response to invading microbes and acts to contain infection in
the first minutes to hours of challenge. Unlike adaptive immunity that relies upon clonal …

Intestinal microbial metabolites are conjectured to affect mucosal integrity through an
incompletely characterized mechanism. Here we showed that microbial-specific indoles …

BACKGROUND: The use of plasma-based resuscitation for trauma patients in hemorrhagic
shock has been associated with a decrease in mortality. Although some have proposed a …

• Introduction• Methods to study and modify the alternative pathway‐Inhibition by
monoclonal antibodies‐Knockout models• Influence of AP amplification on the effect of …

The human collectin, mannose‐binding lectin (MBL), is an important protein of the humoral
innate immune system. With multiple carbohydrate‐recognition domains, it is able to bind to …

Complement research experienced a renaissance with the discovery of a third activation
route, the lectin pathway. We developed a unique model of total lectin pathway deficiency, a …

The complement system is a key element of the innate immune system, and the production
of complement components can be divided into central (hepatic) and peripheral …

Human intestinal ischemia-reperfusion (IR) is a frequent phenomenon carrying high
morbidity and mortality. Although intestinal IR-induced inflammation has been studied …

Mannan-binding lectin (MBL), L-ficolin, M-ficolin and H-ficolin are all complement activating
soluble pattern recognition molecules with recognition domains linked to collagen-like …