This review focuses on MRI contrast agents that are responsive to a change in a
physiological biomarker. The response mechanisms are dependent on six physicochemical …

Glioblastoma (GBM) as the most common primary malignant brain tumor exhibits a high
incidence and degree of malignancy as well as poor prognosis. Due to the existence of …

Stimuli-responsive multimodality imaging agents have broad potential in medical
diagnostics. Herein, we report the development of a new class of branched-bottlebrush …

Integrating an NIR fluorescent probe with a magnetic resonance imaging (MRI) agent to
harvest complementary imaging information is challenging. Here, we have designed water …

Nitroreductase (NTR) is an important biomarker widely used to evaluate the degree of tumor
hypoxia. Although a few optical methods have been reported for detecting nitroreductase at …

Copper (Cu) is an essential micronutrient for most organisms and serves mainly as a redox-
active catalytic centre in enzymes cycling between Cu+ and Cu 2+. Membrane transporters …

Research on bimodal contrast agents in general and optical/MRI contrast agents in
particular has attracted increased attention from the scientific community in recent years …

A new, easily accessible “off-on-off” colorimetric and fluorescent probes are designed and
synthesized. It displayed highly selective and sensitive detection towards Cu 2+ ion without …

Multiple imaging modalities are often required for in vivo imaging applications that require
both high probe sensitivity and excellent spatial and temporal resolution. In particular, MR …

Quinoline based novel fluorescent probes have been synthesized for the selective and
sensitive detection of Cu 2+ ions. The probes FQ-1 and FQ-2 exhibit a turn-on fluorescence …