Human prostate cancer risk factors

DG Bostwick, HB Burke, D Djakiew… - … Journal of the …, 2004 - Wiley Online Library
Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of …

K Gravdal, OJ Halvorsen, SA Haukaas, LA Akslen - Clinical cancer research, 2007 - AACR
Purpose: Cell adhesion molecules are of crucial importance in cancer invasion and
metastasis. Epithelial to mesenchymal transition, characterized by reduced E-cadherin and …

Prostate cancer and the met hepatocyte growth factor receptor.

BS Knudsen, M Edlund - Advances in cancer research, 2004 - europepmc.org
The hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the Met protein
tyrosine kinase, form a classic ligand-receptor system for epithelial-mesenchymal …

Aberrant expression of E-cadherin and beta-catenin in human prostate cancer☆

M Jaggi, SL Johansson, JJ Baker, LM Smith… - … Oncology: Seminars and …, 2005 - Elsevier
Cadherin-catenin complexes play a key role in embryonic development, and are associated
with carcinogenesis and metastasis. We studied the expression of the major members of the …

ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion

C Cai, CL Hsieh, J Omwancha, Z Zheng… - Molecular …, 2007 - academic.oup.com
Androgens and the androgen receptor (AR) act in cells by modulating gene expression.
Through gene microarray studies, we have identified Ets Variant Gene 1 (ETV1) as a novel …

N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin

YH Song, Y Oda, M Hori, K Kuroiwa, M Ono, F Hosoi… - Human pathology, 2010 - Elsevier
N-myc downstream regulated gene-1 (NDRG1)/Cap43 plays an important role in tumor
progression and metastases in many kinds of cancers. Recently, it was reported that …

DLC1 induces expression of E-cadherin in prostate cancer cells through Rho pathway and suppresses invasion

V Tripathi, NC Popescu, DB Zimonjic - Oncogene, 2014 - nature.com
E-cadherin is a cell–cell adhesion molecule that acts as a suppressor of cancer cell invasion
and its expression is downregulated in many advanced, poorly differentiated, human …

Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells

C Cai, J Omwancha, CL Hsieh… - Prostate cancer and …, 2007 - nature.com
Multidrug resistance-associated proteins (MRPs) may mediate multidrug resistance in tumor
cells. Using a gene array analysis, we have identified MRP4 as an androgen receptor (AR) …

Androgen regulation of soluble guanylyl cyclaseα1 mediates prostate cancer cell proliferation

C Cai, SY Chen, Z Zheng, J Omwancha, MF Lin… - Oncogene, 2007 - nature.com
The growth and progression of prostate cancer are dependent on androgens and androgen
receptor (AR), which act by modulating gene expression. Utilizing a gene microarray …

Varicocele-induced testicular dysfunction may be associated with disruption of blood-testis barrier

IT Koksal, Y Ishak, M Usta, A Danisman… - Archives of …, 2007 - Taylor & Francis
The objective of this study was to examine E-cadherin and α-catenin expression at the
junctions between adjacent Sertoli cells in testicular specimens from patients with varicocele …