Synthetic nanoparticles for vaccines and immunotherapy

DJ Irvine, MC Hanson, K Rakhra, T Tokatlian - Chemical reviews, 2015 - ACS Publications
The immune system plays a critical role in our health. No other component of human
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …

Engineering functional polymer capsules toward smart nanoreactors

J Gaitzsch, X Huang, B Voit - Chemical reviews, 2016 - ACS Publications
The design and construction of integrated chemical ensembles for studying complex
biological systems is attracting considerable interest in a wide range of research …

Targeted and equally distributed delivery of mrna to organs with pentaerythritol-based one-component ionizable amphiphilic janus dendrimers

J Lu, EN Atochina-Vasserman, DS Maurya… - Journal of the …, 2023 - ACS Publications
Delivery of nucleic acids with viral and synthetic vectors has pioneered genetic
nanomedicine. Four-component lipid nanoparticles (LNPs) consisting of ionizable lipids …

One-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer delivery systems for mRNA

D Zhang, EN Atochina-Vasserman… - Journal of the …, 2021 - ACS Publications
Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine.
Both viral and synthetic vectors have been successfully employed for genetic delivery with …

The unexpected importance of the primary structure of the hydrophobic part of one-component ionizable amphiphilic Janus dendrimers in targeted mRNA delivery …

D Zhang, EN Atochina-Vasserman, J Lu… - Journal of the …, 2022 - ACS Publications
Viral and synthetic vectors for delivery of nucleic acids impacted genetic nanomedicine by
aiding the rapid development of the extraordinarily efficient Covid-19 vaccines. Access to …

Self-assembly concepts for multicompartment nanostructures

AH Gröschel, AHE Müller - Nanoscale, 2015 - pubs.rsc.org
Compartmentalization is ubiquitous to many biological and artificial systems, be it for the
separate storage of incompatible matter or to isolate transport processes. Advancements in …

Targeted delivery of mRNA with one-component ionizable amphiphilic Janus dendrimers

D Zhang, EN Atochina-Vasserman… - Journal of the …, 2021 - ACS Publications
Targeted and efficient delivery of nucleic acids with viral and synthetic vectors is the key step
of genetic nanomedicine. The four-component lipid nanoparticle synthetic delivery systems …

From structure to function via complex supramolecular dendrimer systems

HJ Sun, S Zhang, V Percec - Chemical Society Reviews, 2015 - pubs.rsc.org
This tutorial review summarizes strategies elaborated for the discovery and prediction of
programmed primary structures derived from quasi-equivalent constitutional isomeric …

Macromolecular metamorphosis via stimulus-induced transformations of polymer architecture

H Sun, CP Kabb, Y Dai, MR Hill, I Ghiviriga… - Nature Chemistry, 2017 - nature.com
Macromolecular architecture plays a pivotal role in determining the properties of polymers.
When designing polymers for specific applications, it is not only the size of a macromolecule …

Dendrimer‐based nanocarriers: a versatile platform for drug delivery

HJ Hsu, J Bugno, S Lee, S Hong - … Reviews: Nanomedicine and …, 2017 - Wiley Online Library
Advances in nanotechnology have had profound impacts on therapeutic delivery, leading to
the development of nanomaterials engineered with large carrying capabilities and targeting …