Parents that kill and consume their offspring often appear to be acting against their own
reproductive interests. Yet parent–offspring cannibalism is common and taxonomically …

With the advent of transgenic and other genetic engineering technologies, the versatility and
usefulness of the mouse as a model in biomedical research has soared. Revised to reflect …

The female reproductive axis is one of the first organ systems to age, which has
consequences for fertility and overall health. Here, we provide a comprehensive overview of …

The ongoing worldwide effort to reduce animal numbers in research often omits the issue of
pre-weaning mortality in mouse breeding. A conservative estimate of 20% mortality would …

Mouse studies continue to help elaborate upon the genetic landscape of mammalian
disease and the underlying molecular mechanisms. Here, we have investigated an Embigin …

Abstract The Cairo spiny mouse (Acomys cahirinus) is a unique animal model for studying
ontogenesis and regeneration. Meanwhile, some peculiarities of its biology, specifically, low …

An environmental enrichment protocol is essential for testing experimental models because
it upholds animal welfare, aligns with ethical principles in animal experimentation, and …

Animal welfare has evolved during the past decades to improve not only the quality of life of
laboratory rodents but also the quality and reproducibility of scientific investigations …

Background Sanfilippo syndrome (mucopolysaccharidosis type IIIA; MPS IIIA) is a childhood
dementia caused by inherited mutations in the sulfamidase gene. At present, there is no …

Relative humidity (RH) is measured in vivaria with a broad range to accommodate seasonal
fluctuations. It is assumed that measurements in the room (macroenvironment) reflect those …