Head and neck squamous cell carcinoma (HNSCC) is currently one of the 10 most common
malignancies worldwide, characterized by a biologically highly diverse group of tumors with …

Head and neck squamous cell carcinoma (HNSCC) arises from the interplay of multiple
factors, such as smoking, alcohol consumption, and viral infections. Cisplatin-based …

Background Pancreatic ductal adenocarcinoma (PDAC) represents an unmet clinical need
due to the very poor prognosis and the lack of effective therapy. Here we investigated the …

Increasing evidence suggests that aerobic glycolysis is related to the progression of oral
squamous cell carcinoma (OSCC). Hence, we focused on glycolysis-related gene sets to …

Mitophagy regulates cancer stem cell (CSC) populations affecting tumorigenicity and
malignancy in various cancer types. Here, we report that cisplatin treatment led to the …

This study reports the design, synthesis and evaluation of a series of histone deacetylase
(HDAC) inhibitors containing purine/purine isoster as a capping group and an N-(2 …

The incidence of oral tongue squamous cell carcinoma has been increasing in young
patients (≤ 45 years) without a clear etiologic driver. It is unknown if younger patients have …

Background Epigenetic dysregulation is essential to the tumorigenesis of oral squamous cell
carcinoma (OSCC). SET and MYND domain-containing protein 3 (SMYD3), a histone lysine …

Objectives The role of tumor‐associated neutrophils (TANs) in the nodal spread of cancer
cells remains unexplored. The present study evaluates the occurrence and clinical …

Tumor growth and metastasis can be promoted by a small sub-population of cancer cells,
termed cancer stem-like cells (CSCs). While CSCs possess capability in self-renewing and …