Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants

MP Soares dos Santos, R Bernardo, L Henriques… - Scientific Reports, 2021 - nature.com
Instrumented implants are being developed with a radically innovative design to significantly
reduce revision surgeries. Although bone replacements are among the most prevalent …

Alternating electric fields modify the function of human osteoblasts growing on and in the surroundings of titanium electrodes

F Sahm, J Ziebart, A Jonitz-Heincke… - International journal of …, 2020 - mdpi.com
Endogenous electric fields created in bone tissue as a response to mechanical loading are
known to influence the activity and differentiation of bone and precursor cells. Thus …

Capacitive technologies for highly controlled and personalized electrical stimulation by implantable biomedical systems

MP Soares dos Santos, J Coutinho, A Marote… - Scientific Reports, 2019 - nature.com
Cosurface electrode architectures are able to deliver personalized electric stimuli to target
tissues. As such, this technology holds potential for a variety of innovative biomedical …

New cosurface capacitive stimulators for the development of active osseointegrative implantable devices

MP Soares dos Santos, A Marote, T Santos, J Torrão… - Scientific reports, 2016 - nature.com
Non-drug strategies based on biophysical stimulation have been emphasized for the
treatment and prevention of musculoskeletal conditions. However, to date, an effective …

Finite element analysis of bone remodelling with piezoelectric effects using an open-source framework

YD Bansod, M Kebbach, D Kluess, R Bader… - … and Modeling in …, 2021 - Springer
Bone tissue exhibits piezoelectric properties and thus is capable of transforming mechanical
stress into electrical potential. Piezoelectricity has been shown to play a vital role in bone …

Establishment of a numerical model to design an electro-stimulating system for a porcine mandibular critical size defect

H Raben, PW Kämmerer, R Bader, U van Rienen - Applied Sciences, 2019 - mdpi.com
Electrical stimulation is a promising therapeutic approach for the regeneration of large bone
defects. Innovative electrically stimulating implants for critical size defects in the lower jaw …

A piezoelectric energy harvesting concept for an energy-autonomous instrumented total hip replacement

HE Lange, D Hohlfeld, R Bader… - Smart Materials and …, 2020 - iopscience.iop.org
To improve the clinical outcome of total hip replacements (THRs), instrumented implants
with sensory functions for implant monitoring and diagnostics or actuators for therapeutic …

Capacitive stimulation-sensing system for instrumented bone implants: Finite element model to predict the electric stimuli delivered to the interface

A Ramos, MPS Dos Santos - Computers in Biology and Medicine, 2023 - Elsevier
Background Prevalence of orthopaedic replacements are increasing around the world. The
main cause of revision remains associated to the interface loosening. In this work, a …

Novel magnetic stimulation methodology for low-current implantable medical devices

R Bernardo, A Rodrigues, MPS Dos Santos… - Medical Engineering & …, 2019 - Elsevier
Recent studies highlight the ability of inductive architectures to deliver therapeutic magnetic
stimuli to target tissues and to be embedded into small-scale intracorporeal medical devices …

Performance of a Piezoelectric Energy Harvesting System for an Energy-Autonomous Instrumented Total Hip Replacement: Experimental and Numerical Evaluation

HE Lange, N Arbeiter, R Bader, D Kluess - Materials, 2021 - mdpi.com
Instrumented implants can improve the clinical outcome of total hip replacements (THRs). To
overcome the drawbacks of external energy supply and batteries, energy harvesting is a …