Recent trends in extraction of plant bioactives using green technologies: A review
Phenolic compounds from plant sources have significant health-promoting properties and
are known to be an integral part of folk and herbal medicines. Consumption of phenolics is …
are known to be an integral part of folk and herbal medicines. Consumption of phenolics is …
Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights
The unexpected emergence of the new Coronavirus disease (COVID-19) has affected more
than three hundred million individuals and resulted in more than five million deaths …
than three hundred million individuals and resulted in more than five million deaths …
Rosmarinic acid exhibits anticancer effects via MARK4 inhibition
Microtubule affinity regulating kinase (MARK4) is a potential drug target for different types of
cancer as it controls the early step of cell division. In this study, we have screened a series of …
cancer as it controls the early step of cell division. In this study, we have screened a series of …
Pharmacological activity of quercetin: an updated review
G Wang, Y Wang, L Yao, W Gu, S Zhao… - Evidence‐Based …, 2022 - Wiley Online Library
Quercetin, a natural flavonoid compound with a widespread occurrence throughout the plant
kingdom, exhibits a variety of pharmacological activities. Because of the wide spectrum of …
kingdom, exhibits a variety of pharmacological activities. Because of the wide spectrum of …
Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy
Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …
Studying the interaction of drug/ligand with serum albumin
S Siddiqui, F Ameen, S ur Rehman, T Sarwar… - Journal of Molecular …, 2021 - Elsevier
The interaction between proteins and drugs/ligands has been explored thoroughly over the
past years. Numerous spectroscopic and in silico tools are employed to decipher the binding …
past years. Numerous spectroscopic and in silico tools are employed to decipher the binding …
Virtual screening approach to identify high-affinity inhibitors of serum and glucocorticoid-regulated kinase 1 among bioactive natural products: Combined molecular …
Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase that works
under acute transcriptional control by several stimuli, including serum and glucocorticoids. It …
under acute transcriptional control by several stimuli, including serum and glucocorticoids. It …
Flavonoids targeting HIF-1: Implications on cancer metabolism
M Samec, A Liskova, L Koklesova, S Mersakova… - Cancers, 2021 - mdpi.com
Simple Summary This comprehensive review discusses the anticancer effects of plant
phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical …
phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical …
MARK4 inhibited by AChE inhibitors, donepezil and Rivastigmine tartrate: insights into Alzheimer's disease therapy
Microtubule affinity-regulating kinase (MARK4) plays a key role in Alzheimer's disease (AD)
development as its overexpression is directly linked to increased tau phosphorylation …
development as its overexpression is directly linked to increased tau phosphorylation …
Ellagic acid controls cell proliferation and induces apoptosis in breast cancer cells via inhibition of cyclin-dependent kinase 6
Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer progression, and thus,
it is considered as an attractive drug target in anticancer therapeutics. This study presents an …
it is considered as an attractive drug target in anticancer therapeutics. This study presents an …