Cryopreservation technology has developed into a fundamental and important supporting
method for biomedical applications such as cell‐based therapeutics, tissue engineering …

In this concept article, we outline a variety of new approaches that have been conceived to
address some of the remaining challenges for developing improved methods of …

Cell-based medicine has made great advances in clinical diagnosis and therapy for various
refractory diseases, inducing a growing demand for cell preservation as support technology …

Cell-based therapeutics promise to transform the treatment of a wide range of diseases
including cancer, genetic and degenerative disorders, or severe injuries. Many of the …

Cellular cryopreservation is a platform technology which underpins cell biology,
biochemistry, biomaterials, diagnostics, and the cold chain for emerging cell-based …

One of the greatest concerns in the subzero storage of cells, tissues, and organs is the ability
to control the nucleation or recrystallization of ice. In nature, evidence of these processes …

Conventional approaches for cell cryopreservation require the use of toxic membrane-
penetrating cryoprotective agents (pCPA), which limits the clinical application of …

Ice formation remains central to our understanding of the effects of low temperatures on the
biological response of cells and tissues. The formation of ice inside of cells and the net …

Dimethylsufoxide (DMSO) being universally used as a cryoprotectant in clinical adoptive cell-
therapy settings to treat hematological malignancies and solid tumors is a growing concern …

The development and use of complex cell-based products in clinical and discovery science
continues to grow at an unprecedented pace. To this end, cryopreservation plays a critical …