Powerful associations that link drugs of abuse with cues in the drug-paired environment
often serve as prepotent relapse triggers. Drug-associated contexts and cues activate …

The elucidation of synaptic density changes provides valuable insights into the underlying
brain mechanisms of substance use. In preclinical studies, synaptic density markers, like …

When neurons are recruited to form the memory engram, they are driven to activate the
expression of a series of immediate-early genes (IEGs). While these IEGs have been used …

Long-term memories are believed to be encoded by unique transcriptional signatures in the
brain. The expression of immediate early genes (IEG) promotes structural and molecular …

The enhancement of complex physiological functions such as cognition and exercise
performance in healthy individuals represents a challenging goal. Adaptive transcription …

Protein kinase Cα (PKCα/PRKCA) is a crucial regulator of circadian rhythm and is
associated with human mental illnesses such as autism spectrum disorders and …

In animals, adaptive transcription is a crucial mechanism to connect environmental
stimulation to changes in gene expression and subsequent organism remodeling. Adaptive …

Transcriptomic responses to neurotransmitters contribute to the complex processes driving
memory and addiction. Advances in both measurement methods and experimental models …

We present analysis of neuronal activity recordings from a subset of neurons in the medial
prefrontal cortex of rats before and after the administration of cocaine. Using an underlying …

In several mammalian species, including humans, complex stimulation patterns such as
cognitive and physical exercise lead to improvements in organ function, organism health …